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KMID : 0363320110320020243
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Journal of Korean Oriental Internal Medicine
2011 Volume.32 No. 2 p.243 ~ p.258
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Lipid-lowering and Antioxidant Effects of Curcuma Radix in Poloxamer 407-induced Hyperlipidemia Model Rat Models
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Park So-Ae
Jo Hyun-Kyung
Yoo Ho-Ryong
Kim Yoon-Sik
Seol In-Chon
An Joung-Jo
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Abstract
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Objectives: This study investigated the hypolipidemic and antioxidant effects of Curcuma radix using a rat model induced by poloxamer 407 injection.
Methods: Serum lipid parameters and oxidative stress-associated biomarkers were determined. Additionally, hepatic cholesterol and triglyceride as well as lipid metabolism-associated gene expressions were observed in hepatic tissue.
Results: 1. Curcuma radix ameliorated elevation of serum cholesterol, triglyceride, LDL-cholesterol, MDA, hepatic cholesterol level, and reduction of serum TAC, SOD, GSH, GSH-reductase level. 2. Curcuma radix augmented up-regulated ACAT gene expression. 3. Curcuma radix almost completely ameliorated down-regulated CYP-7A1 but up-regulated HMG-CoA gene expression.
Conclusions : The hypolipidemic and antioxidant properties of Curcuma radix were evidenced. This study provides a scientific basis for the clinical application of Curcuma radix and development of hypolipidemics using this herb in the future.
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KEYWORD
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Curcuma Radix, hyperlipidemia, poloxamer 407, cholesterol
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